The Effects of Antibiotic Combination Treatments on Pseudomonas aeruginosa Tolerance Evolution and Coexistence with Stenotrophomonas maltophilia
ABSTRACT The Pseudomonas aeruginosa bacterium is a common pathogen of cystic fibrosis (CF) patients due to its ability to evolve resistance to antibiotics during treatments.While P.aeruginosa resistance evolution is well-characterized in monocultures, it is less well-understood in polymicrobial CF infections.Here, we investigated how exposure to ci